In Vitro Tests

We offer a broad range of in vitro studies, backed by many years of experience, state-of-the-art instruments including modern cell culture equipment.

Not only human skin cell cultures (e.g. fibroblasts, melanocytes, keratinocytes) and organotypic skin models (e.g. by SkinEthic™, MatTek) but also skin samples obtained from punch biopsies or the suction blister method can be subjected to a broad range of in vitro analyses:

  • Cytotoxicity testing (NR test, MTT test, WST1 test)
  • Phototoxicity testing (NR test, MTT test, WST1 test)
  • Apoptosis
  • Skin renewal and differentiation (number of proliferating cells within the epidermis, immunohistological staining of the cell nuclei of proliferating cells with antibody Ki67)
    Ki 67 staining
  • Cell metabolism (e.g. ATP content)
  • Irritation testing ( e.g. on reconstructed human epidermis)
  • Gene expression
  • ELISA (e.g. collagen, fibrillin, hyaluronic acid, 8-isoprostane, carbonyl proteins, metallo-proteinases, cytokines)
  • Protein synthesis
  • Anti-oxidant testing (8-isoprostane as a marker for lipid peroxidation, carbonyl proteins as marker for protein oxidation)
  • Immunohistological analyses of UV-induced DNA damage in vitro (thymine dimers, 8-oxo-guanine)
  • Histological and immunohistological analyses
  • Pigmentation and whitening (effect on melanogenesis)
  • Anti-inflammatory effects (e.g. secretion of inflammatory cytokines)
  • Sun protection
  • Differential gene expression via Real Time Quantitative PCR

Please contact us for further information, consultation or a detailed proposal.

 

// Aktuelle Studien

// Contact

Dammtorwall 7a
20354 Hamburg
Germany
Phone: +49 40 - 35 53 81 - 0
Fax: +49 40 - 35 53 81 - 11
E-Mail: skin.hamburg@sgs.com
Web: https://www.institut-fresenius.de/haut

SGS INSTITUT FRESENIUS GmbH – Studien und Probandeninfos

Wir suchen regelmäßig Probanden. Informieren Sie sich hier.

Infos

Download our brochure:
Applied dermatological research for the skin (PDF)

SGS INSTITUT FRESENIUS GmbH works together with the Dermatologikum Hamburg: www.dermatologikum.de

 

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